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    In this months newsletter we will look at a family of drugs called Corticosteroids. These drugs are used for conditions ranging from asthma to ulcerative colitis. We will be looking at some of the interactions with other substances such as vitamins, minerals, herbs, other supplements, and foods. We’ll also take a look at some natural means of reducing inflammation. We’ll also throw in a couple of favorite quotes. Your feedback would be most appreciated as to what you like or don’t like about the newsletter and if you have suggestions for improving it, 
those are always welcome. You can send your suggestions or criticisms to bowtech@nts-online.com .

 

If you want love and acceptance from your family,
then you must have love and acceptance for them.
                                                                                Louise L. Hay

 

 

Corticosteroids:

    Taber’s Cyclopedic Medical Dictionary defines this group of drugs as "any of several hormonal steroid 
substances secreted by the cortex of the adrenal gland. They are classified according to their biological activity as glucocorticoids, mineralocorticoids, and androgens."
    In today’s world, many of these substances are also made synthetically. Both natural and synthetic have anti-inflammatory properties that are very powerful. They are taken orally to treat conditions such as asthma, bursitis, Chroan’s disease, skin disorders, tendonitis, ulcerative colitis, and others. They can also be inhaled to 
treat things such as asthma or other conditions in which breathing is restricted and can also be inhaled through 
the nose for treatment of seasonal allergies. They are sometimes combined with antibiotics to treat ear infection, 
eye infection, and skin infections.

Corticosteroids include:

Beclomethasone (Beconase, Beclovent, Vancenase, Vanceril), Budesonide (Pulmicort, Rhinocort), Dexamethasone (Decadron, Decadron Phosphate Turbinaire, and others), Dexamethasone/Tobramycin (Tobradex), Flunisolide (AeroBid, Nasalide), Fluticasone (Cutivate, Flonase), Hydrocortisone (Cortef, Hytone, and others), Methylprednisalone (Medrol and others), Mometasone (Elocon), Prednisone (Deltasone, Orasone, and others), Prednisalone (Delta-Cortef, Pediapred, and others), and Triamcinolone (Aristocort, Azmacort, Nasacort, and 
others).

Corticosteroid Interactions with Supplements and Herbs

Supplement

Interactions

Vitamin A

Theoretically, vitamin A could reverse some of the beneficial effects of corticosteroids. In some cases, those being treated with corticosteroids will develop impaired wound healing abilities, and it is possible that vitamin A could be of benefit to those individuals. The best way to determine this would be to consult your doctor or a Naturopath to see which situations of improved wound healing would outweigh the theoretical risk associated with the use of vitamin A in conjunction with corticosteroids.

 

Vitamin B6

The loss of vitamin B6 could be increased with the use of corticosteroids. Supplementation of B6 may be necessary to avoid deficiency, but any additional B6 may not provide additional benefit. If taking corticosteroids for longer than 2 weeks it has been recommended that supplementation of 25 to 50 mg of vitamin B6 daily.

Vitamin D & Calcium

The body’s ability to activate vitamin D is reduced when taking corticosteroids, which could result in increased risk of bone loss. A study of people with rheumatoid arthritis showed that supplementation with 1,000mg of calcium and 500mg of vitamin D per day helped maintain bone density. Again, if taking anti-inflammatory steroidal drugs for more than two weeks it would be in your best interest to consult your doctor or Naturopath about supplementing with calcium and vitamin D.

Magnesium

The loss of magnesium may be increased with the use of corticosteroids. Many nutritionally oriented doctors recommend that supplementation of 300 – 400mg of magnesium be taken if taking these drugs for more than 2 weeks.

Potassium

Potassium loss increases with the use of steroidal anti-inflammatory drugs. Fruits are a better source of potassium than most supplements can provide, so eating more fresh fruit can supply you with the needed potassium while on these drugs.

Sodium

Sodium retention can be a problem while on corticosteroids. Check with your doctor to see if you need to restrict the amount of sodium in your diet.

DHEA (Dehydroepiandrosterone)

Low levels of DHEA were found in a group of women with asthma who had been taking beclomethasone compared with a group not taking beclomethasone. There are concerns that this may be part of the reason of how corticosteroids can cause osteoporosis. More research is needed.

NAC (N-Acetyl Cysteine)

In a preliminary study it was found that supplementing with 600mg of NAC (3 times daily) while being treated with Prednisone for Fibrosing Alveolitis, further improvement took place.

Melatonin

The production of melatonin may be suppressed while taking the synthetic corticosteroid called dexamethasone. More research is needed to study long term use in association with melatonin suppression.

Other Nutrients

Although evidence of its importance is unclear, urinary loss of vitamin K, vitamin C, and zinc is increased with the use of corticosteroids.

 

Herbs

Interactions

Aloe Vera

Animal research indicates that aloe vera applied topically with a form of cortisone actually enhanced the cortisones anti-inflammatory actions in the skin.

Foxglove (Digitalis purpurea)

Glycosides contained in digitalis may increase the risk of side effects during corticosteroid therapy.

Ma Huang (Ephedra sinica)

Ephedrine, a chemical that occurs naturally in the herb ephedra, is also available as a drug product. Ephedrine increases the clearance of dexamethasone from the body, which in turn decreases the amount of activity from the drug. It is not known if the herb ephedra has the same effect on dexamethasone, but until more is known it is recommended that both ephedra and ephedrine be avoided.

Licorice (Glycyrrhiza glabra)

Licorice extract has been shown with laboratory animals to decrease the clearance of prednisone from isolated livers. If the same thing happens in humans it could prolong prednisone activity, which could increase prednisone related side effects. Cortisone, the natural hormone most like prednisone, has been shown in studies with animals to be negatively effected with the supplementation of glycyrrhizin (an active constituent of Licorice). Glycyrrhizin was shown to prevent the immuno-suppressive actions of cortisone. Licorice should be avoided while taking corticosteroids unless first consulting with a nutritionally oriented doctor.

 

Interactions with foods and other substances:

Foods:

Corticosteroids should be taken after a meal because they can cause stomach upset if taken on an empty stomach. It is best to take these before 9:00 am.

Protein – Corticosteroids cause protein wasting. Some doctors recommend a high protein diet for those on these drugs for extended periods. Systemic Lupus Erythematosus is one condition treated with steroids and the kidney damage associated with this condition, and the link to high protein diets and kidney damage, it may not be appropriate for all individuals to be on a high protein diet. Consult with your doctor before undertaking such a diet.

Alcohol can increase the irritation caused by corticosteroids on the stomach.

 

Good health is having no fatigue, having a good appetite, going to sleep and awakening easily, having a good memory, having good humor, having precision in thought and action, and being honest, humble, grateful and loving. How healthy are you?
                                                                                                                                                                                            Louise L. Hay

 

Some Herbs with Anti-Inflammatory Properties

Arnica (Arnica Montana) – A very dilute tincture can be used as a gargle and mouthwash for inflammation of the mouth and throat. Should not be used without medical supervision.

Balm of Giliad (Populus candicans) – Useful externally for inflammation due to rheumatism and arthritis.

Borage (Borago officinalis) – This herb has been recommended for pleurisy and peritonitis for its calmative and anti-inflammatory actions.

Chicory (Cichorium intybus) – For painful inflammations, try applying the boiled leaves and flowers wrapped in a cloth.

Coltsfoot (Tussilago farfara) – Useful for inflammations of the respiratory system such as acute or chronic bronchitis, irritating coughs, whooping cough, or asthma. It’s leaves store useful amounts of zinc, which may be why it is so useful as an anti-inflammatory herb.

Comfrey (Symphytum officinale) – For throat inflammations, a gargle and mouthwash of this herb is useful. The FDA says this herb should only be used externally.

Common Mullein (Verbascum thapsiforme) – The tea of the flowers will help relieve pain and induce sleep. Externally on inflammation or painful skin conditions, use the tea or fomentation of the leaves boiled or steeped in hot vinegar and water.

Cucumber (Cucumis sativus) – Apply to inflammations, bed sores, and burns.

Fenugreek (Trigonella foenum-graecum) – It can be taken for bronchitis or fevers and can be gargled for sore throat. A poultice of the pulverized seeds can be used for gouty pain, swollen glands, wounds, or skin irritations.

Ginseng (Panax schin-seng or Panax quinquefolius) – Considered very useful for feverish or inflammatory illnesses.

Gum Plant (Grindelia robusta) – Externally, the tea of this herb can be used as a wash for burns, rashes, blisters, and inflammations.

Hedge Bindweed (Convolvulus sepium) – This herb is primarily used as a purgative, but it is also helpful in reducing inflammation of mucous membranes. Strong Purgative, not for extended use.

Mallow (Malva sylvestris or Malva rotundifolia_ - Useful as a tea for inflammation of the larynx and tonsils. As a poultice to help soothe inflammations externally.

Pokeweed (Phytolacca Americana) – The dried root is useful in relieving inflammations, treating arthritis and rheumatism, and for relieving pain. Fresh or undercooked plant is poisonous, especially the root. The seeds in the berries are also poisonous and particularly hazardous to children.

Sandalwood (Santalum album) – Most of sandalwoods medicinal qualities exist in the oil. The oil can be used for bronchitis as well as inflammation of mucous tissue.

Sarsaparilla (Smilax officianalis) – Useful for gout, rheumatism, colds, fevers, and catarrhal problems.

Slippery Elm (Ulmus fulva) – This herb is one that is very under-used. It is excellent for sensitive or inflamed mucous membrane lining in the digestive system. Can be used in gastritis, gastric or duodenal ulcers, enteritis, colitis, and other similar conditions. With diarrhea it will both soothe and astringe at the same time. Externally, excellent as a poultice for boils, abscesses or ulcers. Useful for inflammation of the mouth and throat, vaginitis, burns, scalds and abrasions, hemorrhoids and anal fissure, varicose ulcers, boils, carbuncles, and inflamed wounds.

Soloman’s Seal (Polygonatum multiflorum) – Mostly used externally as a poultice on inflammations, bruises, and wounds. Also good as a wash for skin problems and blemishes. Hypoglycemics should consult their physician before using Polygonatum odoratum, a European variety that has been used in Chinese medicine for diabetes to help lower blood sugar levels.

White Pond Lily (Nymphaea oderata) – Tea made from the White Pond Lily makes a good gargle for irritation and inflammation of the mouth and throat. It can be used as an eyewash and vaginal douche.

Willow (Salix alba, Salix purpurea, Salix nigra, Salix caprea) – Willow bark has been used for at least 2,000 years to alleviate pain and reduce fever. It reduces inflammation and is an effective treatment for articular rheumatism. As a decoction it can be used for gum and tonsil inflammation.

Wintergreen (Gaultheria proumbens) – Wintergreen oil consists mostly of methyl salicylate, which is closely related to aspirin. The leaves have been used for aches and pains, inflammation, and rheumatism. Can also be used as a gargle for sore mouth and throat.

Witch Hazel (Hamamelis virginiana) – A poultice made from the inner bark is said to be effective for hemorrhoids and for inflammations of the eye.

This list of herbs is in no way meant to be complete as there are thousands of herbs with anti-inflammatory properties. With a little research you can find many more on your own. Don’t take anyone’s word for anything related to your health unless you trust them fully. Do your own research. You’ll be surprised at what you may learn.


Always remember others may hate you but those who hate you don't win
unless you hate them. And then you destroy yourself.
                                                                     Richard M. Nixon (1913 – 1994)

References:

A-Z Guide to drug-herb-vitamin interactions by Healthnotes, Inc. Published in association with Healthnotes Online, Inc. by Prima Publishing; Rocklin, CA. 1999
Prescription for Nutritional Healing 3rd Edition by Phyllis A. Balch, CNC and James F. Balch, M.D.: Avery, a member of Penguin Putnam, Inc. New York, NY: 2000
The Herb Book by John Lust : Bantam Books. New York, New York: 1974
The Little Herb Encyclopedia 3rd Edition by Jack Richason, N.D.; Woodland Health Books; Pleasant Grove, UT: 1995
Taber’s Cyclopedic Medical Dictionary Edited by Clayton L. Thomas, M.D., M.P.H; F. A. Davis Company; Philadelphi, PA 1997
Heart Thoughts A Treasury of Inner Wisdom by Louise L. Hay: Hay House, Inc. Carlsbad, CA: 1990

 

 

 

  

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